Therefore, the dose of methylprednisolone should be titrated to avoid steroid toxicity. Medrol may also be given by injection into the muscle intramuscular, IM or into the vein intravenously, IV by healthcare provider. How should you take Medrol?Return to topTake Medrol exactly as prescribed. If you have diabetes, Medrol may increase your blood sugar levels. Exposure to excessive amounts of benzyl alcohol has been associated with toxicity hypotension, metabolic acidosis particularly in neonates, and an increased incidence of kernicterus, particularly in small preterm infants. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute medrol conveniente leukemia of childhood 10. The following numbers do not provide medical advice, but in the US you may report side effects to the Food and Drug Administration FDA at 1-800-FDA-1088.